Nicotine poisoning for using an electronic cigarette
Numerous sources will tell you that nicotine is three times more poisonous than arsenic, and that you only need 60 mg to kill an adult, but is it really something that vapors need to worry about? Could the vaping be the way to a fatal nicotine overdose? Or do you have to possess a superhuman lung pair and be fumigating high concentration nicotine through a smoke machine to even have a chance that something fatal will happen to you?
With the recent research study of nicotine delivery through first- and new-generation devices and some up-to-date information on nicotine toxicity, it is possible to make a tentative estimate of the potential for nicotine An overdose of nicotine through vaping.
The toxic dose of nicotine The figure of 60 mg (or even as low as 30 mg) for the dose of nicotine that has a 50 percent kill of a human being is even quoted By numerous sources and can be found in a wide range of textbooks, but it is very likely to be just simply a mistake. Bernd Mayer investigated the origin of the rumor and finally found its way to an old textbook containing a rather speculative paragraph based on some experiments carried out in the nineteenth century. The basic procedure involved in the same experimenters giving doses between 1 to 4 mg of nicotine and documenting the effects. Along with things like increased salivation, nausea and vomiting (symptoms that are to be expected in nicotine poisonings), the experimenters reported seizures and loss of consciousness. The problem is that 4 mg of nicotine is the equivalent of smoking around two cigarettes, and if seizures and loss of consciousness were common in this small dose, smoking areas would literally be full of people convulsing.
Hence comes the erroneous estimate of 60 mg for the lethal dose, which has been quite unthinkingly repeated since then. Mayer estimates (based on reports of nicotine concentrations in the plasma of people who had a fatal nicotine overdose, as well as the large doses that people have survived) are more likely to have the necessary concetration for That the nicotine is lethal is between 500 mg and 1000 mg on average in an adult of average size, corresponding to a dose of 6.5 to 13 mg/kg of weight. In terms of plasma concentration, the old estimate assumed a nicotine concentration of 0.18 mg/L, while the new estimate was 4 mg/L.
How much nicotine do you absorb? The only other thing we need to know to make an estimate of how likely it is that a vapor can suffer from nicotine overdose is the amount of nicotine actually Which we absorb when we are vacating. In the study of Dr. Konstantinos Farsalinos mentioned above, the comparison of nicotine absorption is based on an experiment performed with a high-end electronic cigarette, for ten strokes (inhalations) and using a liquid with a concentration of 18 mg/ml for 5 minutes. The result was 6.59 ng/ml . Note that the measure is in ng, ie nanograms, which is a thousandth of a gram, making it very clear that having a nicotine overdose through vaping is highly unlikely.
So, how much would you have to vaccinate to have an overdose?If we simplify a little, you need to inhale 6,070 puffs in about an hour, or more than 100 drafts per minute. As you can imagine, it is not really possible. In addition you would have to be one a very dedicated blower to follow through through vomiting, nausea, stomach ache, fainting and more.
Is there anything to worry about, then?Of course, it would be very unlikely that you could vape your way to an overdose of (except for the exception of superhuman lungs, super high nicotine juice Concentration and vapear directly from a smoke machine from a theatrical setting), but it does not mean that a nicotine poisoning is no concern at all. If you have a 30 ml bottle of 18 mg e-liquid, this is 540 mg in total, which is at the lower end of the toxic dose reviewed for adults. If you act like an idiot and drink it, you will indeed have a very, very bad moment. In addition, nicotine can be absorbed by the skin, so if you were to spill e-liquid (especially high concentration nicotine used for DIY blend) on itself, again there is a very real possibility that Could be fatal. That is why you can not act like an idiot when you are dealing with nicotine.
However, any concern over nicotine overdose in vapors - out of e-liquid stains is far out of place. For children or pets, the concern is more justified (less weight means less nicotine for a deadly dose), but for us, sensitive adult users, nicotine overdose through the vaping Is effectively impossible.